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They are polarized tissues due to the differential expression of ion channels, pumps and transporters in the apical and the basolateral sides: (a) epithelial sodium channels (ENaC), Ca 2+ activated chloride channels and the cystic fibrosis transmembrane conductance regulator (CFTR) are present in the apical plasma membrane and (b) the Na + -K + -ATPase ion pump and the Na + -K + -2Cl cotransporter in the basolateral side

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It activates the mTOR pathway, stimulating enzymes involved in nucleotide production

Investigational Topical Peptide May Help Tame Eczema The new drug silenced cytokine-expressing genes, suppressed skin infiltration by inflammatory cells, and healed skin lesions, all without apparent toxicity, in an animal model